Selected Publications
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Dissecting human monoclonal antibody responses from mRNA- and protein-based XBB.1.5 COVID-19 monovalent vaccines (preprint)
Raianna F. Fantin*, Jordan J. Clark*, Hallie Cohn*, Deepika Jaiswal*, Bailey Bozarth*, Alesandro Civljak, Vishal Rao, Igor Lobo, Jessica R. Nardulli, Komal Srivastava, Jeremy Yong, Robert Andreata-Santos, Kaitlyn Bushfield, Edward S. Lee, Gagandeep Singh, PVI Study Group, Steven H. Kleinstein, Florian Krammer, Viviana Simon, Goran Bajic, Camila H. Coelho
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SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback
Nathaniel Bloom, Sydney I Ramirez, Hallie Cohn, Urvi M Parikh, Amy Heaps, Scott F Sieg, Alex Greninger, Justin Ritz, Carlee Moser, Joseph J Eron, Goran Bajic, Judith S Currier, Paul Klekotka, David A Wohl, Eric S Daar, Jonathan Li, Michael D Hughes, Kara W Chew, Davey M Smith, Shane Crotty, Camila H Coelho, The Accelerating COVID-19 Therapeutic Interventions and Vaccines–2/A5401 (ACTIV-2/A5401) Study Team , SARS-CoV-2 monoclonal antibody treatment followed by vaccination shifts human memory B cell epitope recognition suggesting antibody feedback, The Journal of Infectious Diseases, 2024;, jiae371, https://doi.org/10.1093/infdis/jiae371
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Human antibody responses to circulating monkeypox virus emphasise the need for the first mpox-specific vaccine
Fantin RF & Coelho CH. Human antibody responses to circulating monkeypox virus emphasise the need for the first mpox-specific vaccine. Lancet Microbe. 2024 Jan 11:S2666-5247(23)00365-8. doi: 10.1016/S2666-5247(23)00365-8. PMID: 38219760.
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Mpox vaccine and infection-driven human immune signatures
Cohn H, Bloom N, Cai GY, Clark JJ, Tarke A, Bermúdez-González MC, Altman DR, Lugo LA, Lobo FP, Marquez S; PVI study group; Chen JQ, Ren W, Qin L, Yates JL, Hunt DT, Lee WT, Crotty S, Krammer F, Grifoni A, Sette A, Simon V, Coelho CH. Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study. Lancet Infect Dis. 2023 Nov;23(11):1302-1312. doi: 10.1016/S1473-3099(23)00352-3. Epub 2023 Jul 17. PMID: 37475115.
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Humoral and cellular immune memory to four COVID-19 vaccines
Zhang Z*, Mateus J*, Coelho CH*, Dan JM, Moderbacher CR, Gálvez RI, Cortes FH, Grifoni A, Tarke A, Chang J, Escarrega EA, Kim C, Goodwin B, Bloom NI, Frazier A, Weiskopf D, Sette A, Crotty S. Humoral and cellular immune memory to four COVID-19 vaccines. Cell. 2022, 7;185(14):2434-2451.e17. DOI: 0.1016/j.cell.2022.05.022; PubMed PMID: 35764089; PubMed Central PMCID: PMC9135677.
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SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron
Tarke A*, Coelho CH*, Zhang Z, Dan JM, Yu ED, Methot N, Bloom NI, Goodwin B, Phillips E, Mallal S, Sidney J, Filaci G, Weiskopf D, da Silva Antunes R, Crotty S, Grifoni A, Sette A. SARS-CoV-2 vaccination induces immunological T cell memory able to cross-recognize variants from Alpha to Omicron. Cell. 2022, 185(5):847-859.e11. DOI: 10.1016/j.cell.2022.01.015; PubMed PMID: 35139340; PubMed Central PMCID: PMC8784649.
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A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes
Coelho CH, Tang WK, Burkhardt M, Galson JD, Muratova O, Salinas ND, Alves E Silva TL, Reiter K, MacDonald NJ, Nguyen V, Herrera R, Shimp R, Narum DL, Byrne-Steele M, Pan W, Hou X, Brown B, Eisenhower M, Han J, Jenkins BJ, Doritchamou JYA, Smelkinson MG, Vega-Rodríguez J, Trück J, Taylor JJ, Sagara I, Renn JP, Tolia NH, Duffy PE. A human monoclonal antibody blocks malaria transmission and defines a highly conserved neutralizing epitope on gametes. Nature Communications. 2021, 12(1):1750. DOI: 10.1038/s41467-021-21955-1; PubMed PMID: 33741942; PubMed Central PMCID: PMC7979743.
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A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine
Tang WK*, Coelho CH*, Miura K, Nguemwo Tentokam BC, Salinas ND, Narum DL, Healy SA, Sagara I, Long CA, Duffy PE, Tolia NH. A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine. Immunity. 2023 Feb 14;56(2):433-443.e5. doi: 10.1016/j.immuni.2023.01.012. PMID: 36792576; PMCID: PMC9989938.
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Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing
Coelho CH, Nadakal ST, Gonzales Hurtado P, Morrison R, Galson JD, Neal J, Wu Y, King CR, Price V, Miura K, Wong-Madden S, Alamou Doritchamou JY, Narum DL, MacDonald NJ, Snow-Smith M, Vignali M, Taylor JJ, Lefranc MP, Trück J, Long CA, Sagara I, Fried M, Duffy PE. Antimalarial antibody repertoire defined by plasma IG proteomics and single B cell IG sequencing. JCI Insight. 2020 Nov 19;5(22):e143471. doi: 10.1172/jci.insight.143471. PMID: 33048842; PMCID: PMC7710313.
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Unwanted Feedback: Malaria Antibodies Hinder Vaccine Boosting
Coelho CH, Duffy PE. Unwanted Feedback: Malaria Antibodies Hinder Vaccine Boosting. Cell Host Microbe. 2020 Oct 7;28(4):504-506. doi: 10.1016/j.chom.2020.09.013. PMID: 33031767; PMCID: PMC7540281.